Metabolomics Reveals that Hepatic Stearoyl-CoA Desaturase 1 Downregulation Exacerbates Inflammation and Acute Colitis
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منابع مشابه
1 MEMBRANE TOPOLOGY OF MOUSE STEAROYL - COA DESATURASE 1 Weng
MEMBRANE TOPOLOGY OF MOUSE STEAROYL-COA DESATURASE 1 Weng Chi Man*, Makoto Miyazaki*, Kiki Chu*, and James M. Ntambi* From the Departments of *Biochemistry and ¶Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706 Running Title: Mouse SCD1 Topology Address correspondence to: James M. Ntambi, Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madi...
متن کاملTargeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression
Stearoyl-CoA desaturase 1 (SCD1) is an established molecular target in many primary tumors including breast, lung, pancreatic, colon and hepatocellular carcinomas. However, its potential role in supporting endometrial cancer growth and progression has not yet been determined. In this study, we evaluated the value of SCD1 as a candidate therapeutic target in human endometrial cancer. Compared wi...
متن کاملInvestigation of (Stearoyl-CoA Desaturase 1) SCD1 Gene Polymorphism in Khuzestan Buffalo Population Using PCR-RFLPMethod
Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA). A number of studies support the hypothesis that SCD gene regulation and polymorphism may affect fatty acid composition and fat quality in meat and milk. Single nucleotide polymorphisms in the coding region of the bovine stearoyl-CoA desaturase gene have been predicted to result in ...
متن کاملProbing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance.
Previous studies using stearoyl-CoA desaturase-1-deficient (SCD1-deficient) mice have shown that this enzyme plays an important role in many diseases of altered cellular metabolism including obesity, insulin resistance, and dyslipidemia. Although SCD1 activity is highest in lipogenic tissues such as the liver and adipose tissue, it is also present at lower levels in most tissues. To better unde...
متن کاملLoss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate.
BACKGROUND AND PURPOSE Adipose inflammation is crucial to the pathogenesis of metabolic disorders. This study aimed at identify the effects of stearoyl-CoA desaturase-1 (SCD1) on the inflammatory response of a paracrine network involving adipocytes, macrophages, and endothelial cells. METHODS AND RESULTS Loss of SCD1 in both genetic (Agouti) and diet-induced obesity (high-fat diet) mouse mode...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2008
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2007.12.003